Inhibitory effects of Swietenia macrophylla on myotoxic phospholipases A2
نویسندگان
چکیده
منابع مشابه
A Review on the Phytopharmacological Effect of Swietenia Macrophylla
Most of the medicinal agents are originated from nature and considered as a rich source for producing drugs including modern drugs. Swietenia machrophylla is one of the most important plant of the family, Meliaceae. It is planted widely in Southern Asia and in the Pacific region. This review provides information on its traditional uses, phytochemical and medicinal values. The plant extracts and...
متن کاملSTUDIES ON SOME PHARMACOGNOSTIC PROFILES OF SWIETENIA MACROPHYLLA. King
The aerial parts and seeds of Swietenia macrophylla King (Meliaceae) are used in exotic medicine systems. In the present study, a preliminary phytochemical and few pharmacological profiles were under taken. The physical constans, extractive and ash values were examined. The presence of secondary metabolites in the aerial parts and seeds showed that Swietenia macrophylla is a good source of acti...
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We developed a methodology to predict myotoxicity and neurotoxicity of proteins of the family of Phospholipases A2 (PLA2) from sequence data. Combining two bioinformatics tools, MEME and HMMER, it was possible to detect conserved motifs and represent them as Hidden Markov Models (HMMs). In ten-fold cross validation testing we have determined the efficacy of each motif on prediction of PLA2 func...
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Hydrolysis of surfactant phospholipids by secreted phospholipases A(2) (sPLA(2)) contributes to surfactant dysfunction in acute respiratory distress syndrome. The present study demonstrates that sPLA(2)-IIA, sPLA(2)-V, and sPLA(2)-X efficiently hydrolyze surfactant phospholipids in vitro. In contrast, sPLA(2)-IIC, -IID, -IIE, and -IIF have no effect. Since purified surfactant protein A (SP-A) h...
متن کاملCrystallization and preliminary X-ray diffraction analysis of three myotoxic phospholipases A2 from Bothrops brazili venom.
Two myotoxic and noncatalytic Lys49-phospholipases A(2) (braziliantoxin-II and MT-II) and a myotoxic and catalytic phospholipase A(2) (braziliantoxin-III) from the venom of the Amazonian snake Bothrops brazili were crystallized. The crystals diffracted to resolutions in the range 2.56-2.05 Å and belonged to space groups P3(1)21 (braziliantoxin-II), P6(5)22 (braziliantoxin-III) and P2(1) (MT-II)...
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ژورنال
عنوان ژورنال: Revista Brasileira de Farmacognosia
سال: 2013
ISSN: 0102-695X
DOI: 10.1590/s0102-695x2013000600005